In aesthetic medicine, few innovations have sparked as much buzz in recent years as polynucleotide face injections. Once reserved for regenerative skin support in post-surgical or medical cases, these powerful injectables are now making waves in mainstream aesthetics — and they’re being hailed by many as the next evolution beyond traditional dermal fillers.

So, what’s behind the growing popularity of polynucleotides? And are they actually replacing dermal fillers, or simply offering a new kind of result?

At Mesglo Aesthetic Clinic London, we’re at the forefront of this shift, blending regenerative injectables with precision aesthetic design. In this article, we break down what makes polynucleotides different, when to use them instead of fillers, and how they’re transforming modern facial rejuvenation.

A Personal Note from the Mesglo Team

This question — "Are polynucleotides replacing fillers?" — is one we’ve been asked more and more in recent months. And to be honest, we’re not surprised. Today’s aesthetic client isn’t looking for extremes — they’re looking for balance, subtlety, and real skin health. They want that glow that makes people say, “You look amazing,” without guessing what was done.

At Mesglo, we’ve seen polynucleotides change the game for so many of our clients. These aren’t just cosmetic treatments — they’re cellular rejuvenation therapies. Whether someone’s just beginning their skin journey or they’ve tried filler and want a more natural alternative, polynucleotides offer something unique: the ability to rebuild and regenerate — not just temporarily enhance.

But that doesn’t mean fillers are “out.” We still use dermal fillers every day at Mesglo — especially when it comes to facial contouring, deep support, and structural volume loss. What’s changing is the mindset. We’re using fillers more strategically, in smaller quantities, and pairing them with treatments like polynucleotides to get a smoother, longer-lasting, and far more natural result. https://mesglolondon.co.uk/?p=3980