In the ever-evolving world of aesthetics and regenerative skincare, one molecule is taking the industry by storm: polynucleotides. Known for their remarkable ability to repair, regenerate, and restore the skin at a cellular level, polynucleotides are quickly becoming the gold standard for non-surgical skin rejuvenation—and for good reason.



At Mesglo Aesthetic Clinic London, we are proud to offer advanced polynucleotide therapies for the face, eyes, and scalp. In this article, we’ll explore what polynucleotides are, how they work, and why they’re the molecule everyone’s talking about in 2025.



What Are Polynucleotides?



Polynucleotides (PNs) are biopolymers composed of DNA and RNA fragments, often derived from salmon DNA due to its high biocompatibility with human tissue. In aesthetics, these fragments are used to stimulate deep skin regeneration by activating your body’s own healing and repair mechanisms.



Rather than filling or freezing the skin, polynucleotides work from the inside out, improving:



🔬 Cellular turnover and skin metabolism🧬 DNA repair and fibroblast regeneration💧 Hydration and dermal density⚡ Collagen and elastin synthesis🌿 Reduction in inflammation and oxidative stress



This makes them a powerful alternative to traditional injectables, particularly for patients seeking natural, long-term improvements in skin quality.



How Do Polynucleotides Rejuvenate the Skin?



When injected into the skin, polynucleotides trigger a biochemical cascade that kickstarts tissue regeneration. They work by:



- Activating Fibroblasts – Stimulating the cells responsible for producing collagen and elastin, leading to firmer, more elastic skin.



- Repairing Cellular Damage – Supporting natural DNA repair processes, especially in sun-damaged or ageing skin.



- Improving Hydration – Acting like a molecular sponge, polynucleotides retain water and improve skin hydration from within. https://mesglolondon.co.uk/polynucleotides-the-skin-regeneration-molecule-everyones-talking-about/